Environmental risk assessment (ERA)
Metabolism, Pharmacology (Safety)
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A collection of nonclinical studies & assays; customization is possible.
Acute renal occlusion procedure (for ARF)
Acute renal occlusion procedure (for ARF)
An acute renal occlusion procedure for in vivo models generates a template for human ischemic acute renal failure (ARF).
Typically using reversible rat and mouse models, the ischemic tubular damage is produced by complete occlusion of the renal artery for various time periods.
Despite some functional similarities between the model and human ARF (e.g., decrease in GFR), there are also questionable differences, such as more extensive necrosis of proximal tubules in the animal model.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.