Environmental risk assessment (ERA)
Metabolism, Pharmacology (Safety)
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Acute renal occlusion procedure (for ARF)
Acute renal occlusion procedure (for ARF)
An acute renal occlusion procedure for in vivo models generates a template for human ischemic acute renal failure (ARF).
Typically using reversible rat and mouse models, the ischemic tubular damage is produced by complete occlusion of the renal artery for various time periods.
Despite some functional similarities between the model and human ARF (e.g., decrease in GFR), there are also questionable differences, such as more extensive necrosis of proximal tubules in the animal model.
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