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Effect of Tail RFID Microchips on Growth Kinetics and Immune Response in Preclinical Oncology Mouse Models
National AALAS 2021 -- Mice are the most common laboratory animal for preclinical oncology studies, and because they are socially housed, a simple and efficient method for identifying individuals is required. Some commonly used methods of animal identification (e.g., ear punch), though cost effective, can be prone to human error and can make identification of large numbers of animals difficult. Various types of radiofrequency identification (RFID) microchips are available for animal identification, removing potential sources for human error in the process of animal identification. There are concerns that implant of foreign objects, such as microchips, could affect an animal's immune response to immune-modulating compounds or immuno-oncology tumor models. Many microchips also require a large-gauge needle for insertion in the subcutaneous space, which could interfere locally with a subcutaneous tumor model. To explore if RFID microchips implanted in the base of the tail affected various aspects of an immuno-oncology tumor model, the murine tumor model CT26.WT (colon adenocarcinoma) was evaluated for growth kinetics, response to treatment with anti-mPD-1, proinflammatory cytokine release, and immune cell population differences in various tissues.