Several Cases of Spontaneous Type 2 Diabetes Mellitus in Stock Cynomolgus Monkeys

ESTP Congress 2022 -- A number of different types of diabetes occur in nonhuman primates (NHPs), with type 2 diabetes mellitus (t2dm) being the most commonly reported (Wagner et al. 2012). Clinical features of diabetes in NHPs are similar to those in humans (obesity, insulin resistance, dyslipidemia, pancreatic pathology and further co-morbid conditions). Gestational diabetes mellitus has also been reported in cynomolgus and rhesus monkeys with similar complications (macrosomic infants, risk of future t2dm) as in humans. Diabetes is one of the major risk factors for cardiomyopathy and heart failure in humans. Diabetic cardiomyopathy, clinically diagnosed as ventricular dysfunction in the absence of coronary atherosclerosis or hypertension in diabetic patients, is a cardiac muscle-specific disease that increases the risk of heart failure and mortality (Kanamori et al. 2021).

Copy and paste this URL:

https://biopharma.labcorp.com/latest-thinking/explore-library/detail.html/covance/assetLibrary/posters/RomeikeESTP22.jpg