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Immunohistochemistry (IHC) for Oncology

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Our preclinical oncology team offers in-house histology and immunohistochemistry (IHC) in addition to other in vitro services for oncology, further expanding our extensive list of services to enhance your study. Optimal preservation and structural integrity of samples is ensured by simply moving samples down the hallway to the histology lab in our state-of-the-art facility. 

Our high-quality IHC assays give you a time-efficient read-out on quantitative and qualitative data and can be produced expeditiously that reveal the following:

  • Efficacy of your compound in target tissues
  • Location of biomarkers in tissues
  • Incidence of tumor metastasis
  • Occurrence of tissue transformation into tumors
  • Origin of tumor tissue
  • Prognosis of the animals in the study

Featured IHC Articles:

Services:

  • Normal Tissue
  • Tumor Tissue
  • Xenograft
  • New Marker Validation
  • Immunofluorescence
  • Immunocytochemistry
  • Multiplex – Custom markers with up to four-color immunofluorescence

  • AE1/AE3+5D3

    AE1/AE3+5D3 cytoplasmic positive mouse skin. Cytokeratins are  filamentous proteins detectable in epithelial cells. They can be utilized in tumor differentiation, cell typing, and micrometastasis.

  • CD3

    Mouse CD3 membrane staining in spleen. CD3 is used to identify T cells in normal tissue, as well as T cell neoplasms.

    CD3 membrane staining in spleen

    CD3 staining in 4T1

    CD3 staining in A20

    CD3 staining in CT26

  • CD4

    Mouse CD4 membrane staining in mouse tumor tissue. CD4 is used to identify T helper cells, and plays a role in T cell activation.

    CD4 staining in subcutaneous A20

    CD4 immunofluorescent staining in A20

    CD4 staining in CT26

    CD4 staining in Pan02

  • CD8

    Mouse CD8 membrane staining in subcutaneous CT26 mouse tumor tissue. CD8 is used to identify cytotoxic T cells.

  • CD19

    Human CD19 membrane staining in human tonsil. CD19 is a biomarker for B cells, and plays a role in B cell development.

  • CD20

    Human CD19 membrane staining in human tonsil. CD19 is a biomarker for B cells, and plays a role in B cell development.

  • CD22

    Human CD22 staining in human tonsil. CD22 is found on the surface of mature B cells that functions as an inhibitory receptor for B cell receptor signaling. It is an active target for B cell malignancies and autoimmune disease.

  • CD38

    Mouse CD38 staining in multiple tissues, as indicated. CD38 is found on the surface of many immune cells (CD4+ and CD8+ T cells, B cells, and natural killer cells). It has functions in cell adhesion, signal transduction and calcium signaling and is used as a prognostic marker in leukemia patients with CLL.

    CD38 staining in 4T1

    CD38 staining in A20

    CD38 staining in CT26

    CD38 staining in ID8

  • CD45

    Mouse CD45 membrane staining in A20 tumor tissue. CD45 plays a role in the regulation of T- and B-cell antigen receptor signaling.

     

  • CD163

    Mouse CD163 staining in multiple tissues, as indicated. CD163 is expressed in macrophages and monocytes. Expression may be indicative of inflammation.

    CD163 staining in CT26

  • FoxP3

    Mouse FOXP3 nuclear staining in spleen. FoxP3 is involved in the development and inhibitory function of regulatory T cells.

  • HER2

    Her2 is a human EGF receptor involved in kinase mediated activation of signaling pathways. It is used as a predictive factor and determinant in therapy in cancer treatment.

    Her2 positive cytoplasm in BT474 tumor tissue.

    HER2 Immunofluorescence of SK-OV-3 Cells

  • Ki67

    Human Ki-67 nuclear staining in human tonsil. The Ki-67 protein is associated with cellular proliferation, and can be used as a prognostic tool in cancer.

  • PR

    Human PR positive nuclei in BT474 tumor tissue. Progesterone receptor is involved in activating signaling pathway for hormone stimulation. It can be utilized in determining appropriate drug therapy in cancer treatment.

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