An estimated one in 20 people will develop colon cancer, making it one of the most frequently diagnosed cancers both in men and women. Due to improved screening methods, the overall incidence of colon cancer has declined during the past 20 years. However, it is still projected that only 40% are diagnosed with early stage disease and that 50% of all patients will also develop metastatic disease. Thus, colon cancer remains an important and active area of oncology drug discovery and development. Surgery is the most common treatment option for patients; however, many also receive chemotherapy and sometimes chemotherapy in combination with radiation therapy. Unless diagnosed early, five-year survival rates are still quite low. Today a number of clinical trials are ongoing to evaluate the potential of immunotherapies in colon cancer.
Preclinically, the murine CT26 colon carcinoma line has become a platform model for evaluating the potential of drug combinations with immune checkpoint inhibitor antibodies. It is a highly immunogenic tumor and tends to show objective response rates to a number of commercially available checkpoint inhibitors. We have run this model more than a dozen times in the past nine months, with additional studies being scheduled regularly.
CT26 Responsive to anti-CTLA4 Antibody Treatment