GL261 is one of the most frequently used syngeneic murine glioma models available. We capitalize on our state-of-the-art imaging capabilities to further interrogate the pharmacology of this model by utilizing a GL261 cell line that expresses luciferase (GL261-luc2, Caliper Life Sciences). This allows for longitudinal, in vivo visualization of the tumors growth and response to treatment within the brain via bioluminescence.
At Labcorp, we have the ability for shielded focal radiation delivery to the brain, and more recently we have acquired the Xstrahl Small Animal Radiation Research Platform (SARRP) allowing for pinpoint irradiation of only the tumor sparing the rest of the mouse, including sites critical for mounting an immune response. While overall survival is a common endpoint in preclinical GBM studies, the addition of in vivo imaging endpoints can add further value to the overall study dataset.
In addition to bioluminescence, we have a host of other imaging technologies, including PET, SPECT and CT modalities, to further interrogate parameters related to GBM such as tumor volume, vascular perfusion/permeability, metabolic activity, and edema.
At Labcorp, we offer a combination of multiple syngeneic tumor lines along with in vivo imaging, guided irradiation treatment, and flow cytometry to best evaluate novel immunotherapies. Furthermore, high throughput capabilities allow rapid and automated acquisition of large sample sizes to accommodate the growing complexity of our client’s preclinical studies.
Contact us to design your GL261 study today!