Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women. About 14% of all new cancers are lung cancer. The American Cancer Society’s estimates for lung cancer in the United States for 2018 are:
- About 234,030 new cases of lung cancer (121,680 in men and 112,350 in women)
- About 154,050 deaths from lung cancer (83,550 in men and 70,500 in women)
There are two main types of lung cancer, non-small cell (NSCLC) and small cell (SCLC) lung cancer. NSCLC represents ~85% of all lung cancer cases. Lung cancer mainly occurs in older people, with diagnosis occurring at age 65 or older.
Overall, the chance that a man will develop lung cancer in his lifetime is about 1 in 15; for a woman, the risk is about 1 in 17. These numbers include both smokers and non-smokers. For smokers the risk is much higher, while for non-smokers the risk is lower. The lung cancer rate has been dropping among men over the past few decades, but only for about the last decade in women. Many contribute this decline to the significant anti-smoking campaigns and the efforts to keep young adults from ever trying it.
As with all cancer prognoses it is highly dependent on how early the cancer is found. If discovered early, the prognosis can be very favorable, even curative. However, since many people live asymptomatically for many years early detection is challenging.
Treatment options for NSCLC are surgery, radiation, chemotherapy, targeted therapy, and immunotherapy. In many cases, a combination of multiple treatment types is used. In the last few years there have been several new targeted and immune based therapies approved by the FDA. These drugs are the result of hundreds of hours of preclinical research evaluating novel therapies in cell and animal models.
NSCLC continues to be a histotype of great interest in the research community due to the high rate of new cases diagnosed annually. Targeted therapy has been widely successful but acquired resistance is a recurring issue. To support preclinical research needs, Labcorp has several well optimized non-small cell lung cancer lines (See Table 1). In this Model Spotlight we highlight a few of our more commonly used lines. (For a complete list of our tumor models click here.)
Table 1: Non-small Cell Lung Cancer Lines Available at Labcorp