Fig. 6: Pan02 response to radiation and checkpoint inhibitor combination.
Future Work with the Pan02 Model
Studies are underway to evaluate the potential of using multiple combinations to improve treatment response in the subcutaneous Pan02 model. In addition, we have recently generated a luciferase-enabled Pan02 cell line to support studies in the orthotopic setting.
1Hidalgo M. Pancreatic cancer. N Engl J Med. 2010 Apr 29;362(17):1605-17.
2SEER Cancer Stat Facts. National Cancer Institute, NIH. (https://www.cancer.gov).
3Pancreatic Cancer Action Network (https://www.pancan.org/).
4Gunderson AJ, Yamazaki T, McCarty K et al. Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma. Plos One 2019, 14(2): e0211117.
5Kabacaoglu D, Ciecielski KJ, Ruess DA and Algul H. Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: current limitations and future options. Frontiers in Immunology 2018, 9:1876.
6Saung MT and Zheng L. Current standards of chemotherapy for Pancreatic cancer. Clin. Ther. 2017,39(11):2125-2134.
7Azad A, Lim SY, D’Costa Z et al. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO, Molecular Medicine 2017, 9(2):167-180.
8Lauffer DC, Kuhn PA, Kueng M et al. Pancreatic cancer: Feasibility and outcome after radio-chemotherapy with high dose radiotherapy for non-resected and R1 resected patients. 2018. Cureus 10(5): e2713.
9Javle M, Golan T and Maitra A. Changing the course of pancreatic cancer – focus on recent translational advances. Cancer Treatment Reviews. 2016; 44:17-25.
10Gajiwala S, Torgeson A, Garrido-Laguna I, Kinsey C, and Lloyd S. Combination immunotherapy and radiation therapy strategies for pancreatic cancer – Targeting multiple steps in the cancer immunity cycle. J Gastro Oncol, 2018; 9(6):1014-1026.
11Corbett TH, Roberts BJ, Leopold WR, Peckham JC, Wilkoff LJ, Griswold DP Jr, Schabel FM Jr. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res. 1984, 44:717-726.
Note: Please note that all animal care and use was conducted according to animal welfare regulations in an AAALAC-accredited facility with IACUC protocol review and approval.