Ovarian cancer is considered a relatively rare gynecologic malignancy but has one of the highest mortality rates due to the non-specific symptoms that occur in early stage disease. This results in most women being diagnosed with advanced stage disease. The incidence of ovarian cancer within the United States is approximately 22,000 cases per year and results in approximately 14,000 deaths per year.
Even though a number of advances have been made in cancer treatments and surgical approaches, little progress in ovarian cancer therapy has provided a meaningful impact on this patient population. While initial response rates can be high, more than 80% of patients will relapse after front-line therapy and over 50% of these women will die within 5 years of diagnosis.
Limited second-line options in 1st line refractory patients along with late stage diagnosis both contribute to the poor overall survival and make this a highly unmet medical need that has been an active area of oncology drug discovery. Recent success with immunotherapies in other cancers provides some hope for ovarian cancer patients. One of the most promising pieces of data reported that the presence of tumor infiltrating lymphocytes positively correlated with improved overall survival of ovarian cancer patients.
ID8 Murine Ovarian Carcinoma Model for Use as a Preclinical Syngeneic Model
At Labcorp we have established the ID8 murine ovarian carcinoma model as a preclinical syngeneic model that can be used to track and monitor disease progression and therapeutic outcomes. Our model relies on the intraperitoneal delivery of luciferase-expressing ID8 cells to mimic aspects of human disease. Following implantation in vivo, the ID8-luc cells demonstrate a 7-8 day tumor doubling time and a median overall survival of approximately 40-50 days. Body weight loss over time has not been observed in this model. However, weight gain is common due to accumulation of peritoneal ascites associated with late-stage disease (Figures 1A, B, C).
Fig. 1: In Vivo Evaluation of ID8-luc Model in C67BL/6 Mice Over Time