While compartmental PK studies evaluate a drug's ADME properties between a number of interconnected and homogeneous compartments, compartmental PK modeling and analysis makes assumptions and develops mathematical models (even when experimental parameters have been altered) to describe and predict those drug's pharmacokinetics.
Compartmental PK Overview
- Describes mathematically how a drug moves through various compartments in the body.
- Predicts how a PK profile changes with altered doses or dose regimens.
- Informs study design optimization for the entire development cycle
- Can predict PK profiles in other species (including human) using scaling techniques.