Covance Is Now Labcorp Drug Development

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Vaccines and Immunology

Understanding immune response, dedicated vaccine lab, adjacent genomics and microbiology expertise.

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Molecular Assays  Immunoassays Functional and Cell-Based Assays

PCR assays:

  • Viral Load Assays; HBV, HCV, HIV, CMV, RSV, HDV, HRV, FLU (Roche, Abbott, in-house LDT)
  • HCV Genotyping (GenMark)
  • Qualitative PCR detection assays

Reverse-hybridization assays:

  • HCV and HBV genotyping (GenMark RVP)

Sequencing Assays:

Dye Terminator (Sanger)

  • Bacterial identification
  • HCV Genotyping

Next Generation:

  • HIV/SIV env (Ab)
  • HIV gag (CTL)
  • FLU NA, HA
  • RSV F, G, SH
  • HBV WGS (C,P,S,X)
  • HDV WGS, ΔAg

Specialty assays:

  • HIV coreceptor tropism
  • Clonal analyses
  • Epitope mapping
  • Virus panels

Additional specialty assays can be seamlessly accessed through LabCorp including Monogram Biosciences, a member of LabCorp’s Specialty Testing Group.

 

 

Immunochemistry and biomarker assays supported in facilities including BSL3 environment:

  • Enzyme-Immuno-Assays (EIA)
  • Radioimmunoassays (RIA)
  • Antibody titers in various matrices
  • Antigen-Antibody binding assays employing Biacore and Octet platforms
  • Measurement of cytokine levels and other biomarkers in various matrices using a variety of immunoassay platforms including ELISA, Meso Scale Discovery (MSD), Luminex, Gyros and Singulex

 

 

 

Flow Cytometry:      

  • Immunophenotyping
  • Immune cell activation and proliferation markers
  • Immune cell mediated killing (including T-cell and NK-cell mediated killing)
  • Intracellular cytokine staining
  • Viral Ab binding

Cell based assays:           

  • T-cell proliferation assay
  • Cytokine release assay
  • Enzyme Linked ImmunoSpot (ELISPOT) assay
  • Assays to determine antibody associated functions such as Complement Dependent Cytotoxicity (CDC), Antibody Dependent Cellular Cytotoxicity (ADCC)
  • Neutralizing Ab Assays
    • HIV/SIV
    • FLU
    • RSV
    • Ebola

Bactericidal assays:

  • OPA - Opsonophagocytic activity assay 
  • SBA -  Serum Bactericidal Activity assay

 

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