Efficacy testing of rabies vaccine and antiviral candidates faces unique challenges due to the lethal nature of the rabies virus and the ease with which it is transmitted. The in vivo phases of these studies require vivarium facilities with the appropriate containment levels and knowledgeable, experienced staff. Rabies studies are often performed in various species including rodents, companion animals (canines and felines) and primates.
We have more than 25 years of experience in testing various vaccine types, including subunit, DNA, RNA and others. As a full-solution provider, we offer both in vivo and in vitro testing services for immunogenicity and efficacy evaluation of your rabies vaccine. Our Denver, Pennsylvania site offers more than 60,000 square feet of vivarium space, including BSL2 containment, as well as trained staff with rabies testing experience in a variety of host species.
Based on the regulatory requirement for rabies vaccine testing, we also offer Duration of Immunity (DOI) studies, including one- and three-yearlong vaccination phases followed by viral challenge at either a single site or multiple geographic locations.
Serum samples from the in vivo phases are analyzed for antibody titers and neutralization activity, and selected tissue samples (brain stems) are titrated for viral load determination. In vitro analysis is performed in-house in our newly renovated labs and through a partnership with world-renowned laboratories for specialized testing (i.e., Rapid Florescent Focus Inhibition Test [RFFIT]).