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Comparative in vitro metabolism studies are a key step in helping to establish the potential mammalian toxicity of a crop protection product. The exact metabolism of a crop protection product will vary between species meaning that different species may be exposed to unique metabolites at varying concentrations. To evaluate human safety, it is essential to test the toxicity of all potential human metabolites and that requires the selection of an animal model, or models, that reflect the full metabolism of the crop protection product that occurs in humans.
Our Capabilities
Comparative in vitro metabolism studies designed for your crop protection product
With no set test guidelines for comparative in vitro metabolism studies, you need a partner with insight and practical experience in designing and conducting these studies targeted to the specific physicochemistry of your crop protection product. Covance can develop a tiered testing approach that screens metabolite profiles across test species to identify those most appropriate for use in toxicology studies. As well as being a requirement in some regulatory environments, this can also help you invest strategically in your toxicology studies.
