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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
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The Effect on Body Weight of Rats After Varying Durations of Inhalation Administration Compared with Oral Administration
SOT 2022 -- To assess the safety of pharmaceutical or biopharmaceutical drugs and to allow industry to manufacture and distribute chemicals, there are regional or country-specific regulatory frameworks that the companies are required to adhere to with the aim of saving lives, improving the health of patients and improving and protecting human health and the environment through evaluation of those chemicals. As part of these assessments, there are certain study types that are required to be conducted. For pharmaceutical development, a 13- or 26-week study is required to enable Phase II or III clinical trials, whilst for chemicals, an OECD 13-week study is required, depending on the tonnage band. The route of administration for pharmaceuticals is dependent on the company's development strategy, whilst chemical study conduct is based on the likelihood of exposure. A comparison of 13-week studies with different dosing regimens using the same rat strain was conducted to assess the impact of inhalation restraint on body weight on control group animals. Data were averaged from the control groups of randomly selected studies for the 3 different dosing scenarios.
