Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
Development of an In Vitro Assay for Assessment of IL-2 Independent CAR T Proliferation
ASGCT 2022 -- CAR T cells must not persist or expand beyond their therapeutic window. Preclinical animal studies of CAR T cell persistence are expensive, lengthy and may not detect persistent CAR T cells across matrices. We have developed a cell viability and proliferation assay to track CAR T cell persistence in vitro. Our in vitro assay provides an additional safety assessment for CAR T cell products to fail early before the costly investments in preclinical and clinical studies.