Syngeneic MC38 Mouse Colorectal Tumor Model: Immune Profile and Response to Immunomodulatory Agents and Radiation

AACR 2021 -- With 53,200 deaths expected in 2020, colorectal cancer (CRC) is the second most common cause of cancer deaths in the U.S. There is a need to develop safe and effective treatments since not all patients or tumors respond to current therapies and the use of appropriate animal models remains vital. The MC38 murine CRC cell line, derived from a grade-III adenocarcinoma chemically induced in a female C57BL/6 mouse, is a widely used CRC model. The immune infiltration in subcutaneous MC38 tumors was analyzed by flow cytometry. Response to checkpoint inhibitors, co-stimulatory antibodies alone or in combination with radiotherapy was determined.

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